Deborah Burnett

Senior Lecturer

Deborah’s background in veterinary medicine kindled her interest in immunology. She undertook her honours at WEHI investigating the genetic pathways which regulate blood clotting. In 2019, she completed a PhD at the Garvan Institute researching the role of antibodies in protective immune responses and autoimmunity. Deborah’s PhD made profound discoveries which redefined the role of antibodies in health and disease and led to first author publications in prestigious journals including Science, Cell and PNAS. The significance of her discoveries were acknowledged in her receipt of the “Garvan Best PhD Thesis”, the “UNSW Dean’s Award” and the “UNSW Faculty of Medicine Award” for Outstanding Contribution to Research.

With the emergence of the COVID19 pandemic Deborah pivoted her expertise to explore vaccination strategies to induce antibodies resistant to viral escape. This resulted in discoveries published in Immunity, Nature Microbiology, EJI, mAbs and Cell Reports Medicine. This work led Deborah to receive a highly commended Discovery Award from Research Australia in 2022.

Deborah currently co-leads collaborative initiatives that span research institutions and hospitals, her focus is on enhancing vaccine efficacy against challenging infectious threats including those linked to autoimmune diseases.

In 2023 Deborah was awarded one of 4 Australian "Loreal-UNESCO For Women in Science" Fellows, and 2023 the Premier's Prize for Early Career Researcher of the Year (Biological Sciences).

 

Journal articles
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Burnett DL; Moxon A; Aggarwal A; Jackson KJL; Cotter C; Akerman A; Russell A; Kalman R; Langley D; Henry JY; Christ D; Bull RA; Brink R; Kelleher AD; Jäck HM; Turville S; Moss B; Goodnow CC, 2026, 'Humoral epitope dominance and immune imprinting by SARS-CoV-1 and SARS-CoV-2 vaccines', Immunology and Cell Biology, 104, pp. 150 - 167, http://dx.doi.org/10.1111/imcb.70072
2026
Jara CJ; Zachariah S; Jackson KJL; Peters TJ; Masle-Farquhar E; Burnett DL; Lam E; Faulks M; Russell A; Miosge L; Smith S; Tscharke DC; Brink R; Goodnow CC; Reed JH, 2025, 'Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody', Proceedings of the National Academy of Sciences of the United States of America, 122, http://dx.doi.org/10.1073/pnas.2522257122
2025
Barnet MB; Jackson KJL; Masle-Farquhar E; Russell A; Burnett DL; Chye A; Jara CJ; Faulks M; Mawson A; Peters TJ; Brink R; Wright K; Allen I; Junankar S; Davis ID; Heller G; Khan Z; Bruce J; Yang C; Prokopec S; Pugh T; Behren A; Hold GL; Zhang F; Cooper WA; Gao B; Nagrial A; Joshua AM; John T; Peters G; Hui R; Boyer M; Blinman PL; Kao SC; Cebon J; Goodnow CC, 2025, 'Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy', Proceedings of the National Academy of Sciences of the United States of America, 122, http://dx.doi.org/10.1073/pnas.2314258122
2025
Stewart EL; Burnett DL, 2025, 'IL-9 and ZBTB18 are germinal center memory makers', Immunity, 58, pp. 773 - 775, http://dx.doi.org/10.1016/j.immuni.2025.03.010
2025
Mazigi O; Langley DB; Henry JY; Burnett DL; Sobti M; Walker GJ; Rouet R; Balachandran H; Lenthall H; Jackson J; Ubiparipovic S; Schofield P; Brown SHJ; Schulz SR; Hoffmann M; Pöhlmann S; Post J; Martinello M; Ahlenstiel G; Kelleher A; Rawlinson WD; Turville SG; Bull RA; Stewart AG; Jäck HM; Goodnow CC; Christ D, 2025, 'Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies', Proceedings of the National Academy of Sciences of the United States of America, 122, http://dx.doi.org/10.1073/pnas.2417544121
2025
Khoury DS; Cromer D; Bailey B; Khan SR; Burnett DL; Kent SJ; Rudd BD; Marchant A; Turner T; Davenport MP, 2025, 'Towards evidence-based immunology', Nature Immunology, 26, pp. 980 - 982, http://dx.doi.org/10.1038/s41590-025-02180-0
2025
Dvorscek AR; McKenzie CI; Stäheli VC; Ding Z; White J; Fabb SA; Lim L; O'Donnell K; Pitt C; Christ D; Hill DL; Pouton CW; Burnett DL; Brink R; Robinson MJ; Tarlinton DM; Quast I, 2024, 'Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity', Immunity, 57, pp. 2433 - 2452.e7, http://dx.doi.org/10.1016/j.immuni.2024.08.017
2024
Burnett DL; Bull RA, 2023, 'Total recall? Understanding the effect of antigenic distance on original antigenic sin', Immunology and Cell Biology, 101, pp. 377 - 380, http://dx.doi.org/10.1111/imcb.12638
2023
Burnett DL; Barnet MB; Moxon A; Tsang V; Samaras K, 2023, 'Editorial: Decoding checkpoint inhibitor-induced immune-related adverse events, volume II', Frontiers in Endocrinology, 14, http://dx.doi.org/10.3389/fendo.2023.1317220
2023
Barnet M; Masle-Farquhar E; Singh M; Burnett DL, 2023, 'Blood and guts: peripheral immune correlates of immunotherapy-induced colitis', Immunology and Cell Biology, 101, pp. 12 - 15, http://dx.doi.org/10.1111/imcb.12604
2023
Rouet R; Henry JY; Johansen MD; Sobti M; Balachandran H; Langley DB; Walker GJ; Lenthall H; Jackson J; Ubiparipovic S; Mazigi O; Schofield P; Burnett DL; Brown SHJ; Martinello M; Hudson B; Gilroy N; Post JJ; Kelleher A; Jäck HM; Goodnow CC; Turville SG; Rawlinson WD; Bull RA; Stewart AG; Hansbro PM; Christ D, 2023, 'Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-36295-5
2023
Tangye SG; Burnett DL; Bull RA, 2022, 'Getting to the (germinal) center of humoral immune responses to SARS-CoV-2', Cell, 185, pp. 945 - 948, http://dx.doi.org/10.1016/j.cell.2022.02.018
2022
Schulz SR; Hoffmann M; Roth E; Pracht K; Burnett DL; Mazigi O; Schuh W; Manger B; Mielenz D; Goodnow CC; Christ D; Pöhlmann S; Jäck HM, 2022, 'Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies', European Journal of Immunology, 52, pp. 970 - 977, http://dx.doi.org/10.1002/eji.202249841
2022
Chye A; Allen I; Barnet M; Burnett DL, 2022, 'Insights Into the Host Contribution of Endocrine Associated Immune-Related Adverse Events to Immune Checkpoint Inhibition Therapy', Frontiers in Oncology, 12, http://dx.doi.org/10.3389/fonc.2022.894015
2022
Young C; Lau AWY; Burnett DL, 2022, 'B cells in the balance: Offsetting self-reactivity avoidance with protection against foreign', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.951385
2022
Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG; Ruiz Silva M, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7
2022
Burnett DL; Barnet MB; Samaras K, 2022, 'Editorial: Decoding checkpoint inhibitor-induced endocrinopathies', Frontiers in Endocrinology, 13, http://dx.doi.org/10.3389/fendo.2022.987648
2022
Burnett DL; Jackson KJL; Langley DB; Aggrawal A; Stella AO; Johansen MD; Balachandran H; Lenthall H; Rouet R; Walker G; Saunders BM; Singh M; Li H; Henry JY; Jackson J; Stewart AG; Witthauer F; Spence MA; Hansbro NG; Jackson C; Schofield P; Milthorpe C; Martinello M; Schulz SR; Roth E; Kelleher A; Emery S; Britton WJ; Rawlinson WD; Karl R; Schäfer S; Winkler TH; Brink R; Bull RA; Hansbro PM; Jäck HM; Turville S; Christ D; Goodnow CC, 2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019
2021
Rouet R; Mazigi O; Walker GJ; Langley DB; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry JY; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull RA; Turville S; Stewart AG; Goodnow CC; Rawlinson WD; Christ D, 2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', Mabs, 13, http://dx.doi.org/10.1080/19420862.2021.1922134
2021
Abayasingam A; Balachandran H; Agapiou D; Hammoud M; Rodrigo C; Keoshkerian E; Li H; Brasher NA; Christ D; Rouet R; Burnet D; Grubor-Bauk B; Rawlinson W; Turville S; Aggarwal A; Stella AO; Fichter C; Brilot F; Mina M; Post JJ; Hudson B; Gilroy N; Dwyer D; Sasson SC; Tea F; Pilli D; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA; Burnett D, 2021, 'Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection', Cell Reports Medicine, 2, pp. 100228, http://dx.doi.org/10.1016/j.xcrm.2021.100228
2021
Burnett DL; Schofield P; Langley DB; Jackson J; Bourne K; Wilson E; Porebski BT; Buckle AM; Brink R; Goodnow CC; Christ D, 2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 22341 - 22350, http://dx.doi.org/10.1073/pnas.2005102117
2020
Stokol T; Yeo WM; Burnett D; DeAngelis N; Huang T; Osterrieder N; Catalfamo J, 2020, 'Erratum: Equid herpesvirus type 1 activates platelets (PLoS ONE (2015) 10: 4 (e0122640) DOI: 10.1371/journal.pone.0122640)', Plos One, 15, http://dx.doi.org/10.1371/journal.pone.0237679
2020
Burnett DL; Bertzbach LD, 2020, 'The importance of veterinary specialized generalists in biomedical research', Research in Veterinary Science, 129, pp. 185 - 186, http://dx.doi.org/10.1016/j.rvsc.2020.02.003
2020
Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
2020
Burnett DL; Reed JH; Christ D; Goodnow CC, 2019, 'Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity', Immunological Reviews, 292, pp. 61 - 75, http://dx.doi.org/10.1111/imr.12808
2019
Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859
2018
Langley DB; Crossett B; Schofield P; Jackson J; Zeraati M; Maltby D; Christie M; Burnett D; Brink R; Goodnow C; Christ D, 2017, 'Structural basis of antigen recognition: Crystal structure of duck egg lysozyme', Acta Crystallographica Section D Structural Biology, 73, pp. 910 - 920, http://dx.doi.org/10.1107/S2059798317013730
2017
Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50
2017
Burnett DL; Cave NJ; Gedye KR; Bridges JP, 2016, 'Investigation of cell-free DNA in canine plasma and its relation to disease', Veterinary Quarterly, 36, pp. 122 - 129, http://dx.doi.org/10.1080/01652176.2016.1182230
2016
Stokol T; Yeo WM; Burnett D; DeAngelis N; Huang T; Osterrieder N; Catalfamo J, 2015, 'Equid herpesvirus type 1 activates platelets', Plos One, 10, http://dx.doi.org/10.1371/journal.pone.0122640
2015
Josefsson EC; Burnett DL; Lebois M; Debrincat MA; White MJ; Henley KJ; Lane RM; Moujalled D; Preston SP; O'Reilly LA; Pellegrini M; Metcalf D; Strasser A; Kile BT, 2014, 'Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms4455
2014
Burnett DL; Burnett L, 2010, 'A rare granulomatous reaction to Q fever vaccination following influenza vaccination.', The Medical Journal of Australia, 193, pp. 60 - 60
2010
Conference Papers
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Barnet MB; Masle-Farquhar E; Russell A; Burnett DL; Jackson KJL; Brink R; Heller G; Yang C; Prokopec S; Behren A; Davis ID; Peters GD; Boyer MJ; John T; Nagrial A; Gao B; Blinman P; Kao SC-H; Cebon JS; Goodnow CC, 2023, 'Association of common inherited NOD2 mutations with exceptional response to immune checkpoint inhibitors', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023
2023
Preprints
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Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies, http://dx.doi.org/10.1101/2020.12.14.422791
2020

 

2023 NSW Premiers Award for Early Career Biological Researcher of the Year

2023 L’Oréal-UNESCO Women in Science Fellowship

2022 Highly Commended, Griffith University Discovery Award at the Annual Health and Medical Research Awards by Research Australia

2022 Publication of the Quarter, St Vincent’s Clinical School, UNSW Medicine

2019 Outstanding Contribution to Research by a Higher Degree Student, UNSW Medicine Education and Research Awards

2019 Dean’s Award for Outstanding PhD Theses, UNSW Graduate Research School

2019 Garvan Best PhD Thesis Award

2015 - 2018 Research Excellence Award, University of NSW

2015 - 2018 Australian Postgraduate Award, University of NSW

2018 Publication of the Year Award, Immunology and Cell Biology Journal

2018 New Investigator Finalist, Australian Society of Immunology

Her work is currently supported by several prestigious research grants including an NHMRC Investigator and Ideas Grant, an NSW OHMR RNA future Leaders Fellowship and a Perpetual Impact Grant. 

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