Susan Clark

Conjoint Professor

Professor Susan Clark, PhD, FAA, FAHMS, is internationally recognized for her pioneering research in cancer epigenetics and epigenomics.  She is currently NHMRC Senior Principal Research Fellow and Research Director, Epigenetics Laboratory, at the Garvan Institute of Medical Research in Sydney, Australia.

The techniques Susan developed in the early 1990s and 2000s, including bisulphite single molecule methylation sequencing and bisulphite-based PCR methods, helped to revolutionize the impact of epigenetic research in embryonic development and human disease and led to commercialization of methylation tests for cancer management. Using the growing suite of epigenomic sequencing technologies and bioinformatic analyses, her laboratory has made ground-breaking discoveries relating to alterations of epigenomic patterns in cancer genomes, including the concept of long-range epigenetic deregulation spanning large-scale 3D domains associated with changes in replication timing and co-ordinate gene silencing and activation.

Susan was an inaugural member of the NIH steering committee that established the Epigenome Roadmap, a member of the management committee of the International Human Epigenome Consortium (IHEC) and on the advisory board of the European “BluePrint” IHEC consortium and led the formation and resided as long-standing president of the AEpiA (Australian Epigenetics Alliance).

During her career, Prof Clark has authored >140 peer-reviewed research articles, 30 reviews and 9 book chapters. Her publications have received >24,000 citations. She has received a number of National and International Awards including the German “Biochemisch Analytik Preis” for outstanding contribution for Methylation analysis (2004); Fellow of the World Technology Network for Biotechnology (2006), Australia’s "Top Ten" National Health and Medical Research (NHMRC) Project Scientists (2009) and Rotary Award for Vocational Excellence (2012). In 2015 she was elected a Fellow of the Australian Academy (FAA); in 2017 Ramaciotti Foundation National Medal of Excellence and in 2019 NSW Premiers Prize for Excellence in Medical Biological Sciences and in 2020 elected a Fellow of the Australian Academy of Health and Medical Sciences, (FAHMS).

 

PUBLICATIONS
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Book Chapters
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Warton K; Stirzaker C; Samimi G; Clark S, 2022, 'DNA Methylation Analysis of Circulating DNA Biomarkers', in Cell-Free Circulating DNA: Purification and Analysis Techniques, WORLD SCIENTIFIC, pp. 247 - 277, http://dx.doi.org/10.1142/9789811244681_0009
2022
Sibbritt T; Schumann U; Shafik A; Guarnacci M; Clark SJ; Preiss T, 2022, 'Target-Specific Profiling of RNA m5C Methylation Level Using Amplicon Sequencing', in Post-Transcriptional Gene Regulation, pp. 375 - 392, http://dx.doi.org/10.1007/978-1-0716-1851-6_21
2022
Sibbritt T; Shafik A; Clark SJ; Preiss T, 2016, 'Nucleotide-Level Profiling of m⁵C RNA Methylation.', in Post-Transcriptional Gene Regulation, pp. 269 - 284, http://dx.doi.org/10.1007/978-1-4939-3067-8_16
2016
Guerrero-Bosagna CM; Clark SJ, 2011, 'We are what we eat: how nutritional compounds such as isoflavones shape our epigenome', in Niculescu MD; Haggarty P (ed.), Nutrition in Epigenetics, Wiley-Blackwell, Oxford, UK, pp. 249 - 261, http://dx.doi.org/10.1002/9780470959824.ch15
2011
Coolen MW; Clark SJ, 2011, 'Genome-wide DNA Methylation Analysis', in Craig JM; Wong NC (ed.), EPIGENETICS: A REFERENCE MANUAL, CAISTER ACADEMIC PRESS, pp. 371 - 392, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293148200022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Clark SJ, 2004, 'Studying mammalian DNA methylation: Bisulfite modification', in DNA Methylation: Approaches, Methods, and Applications, pp. 53 - 64, http://dx.doi.org/10.1201/9780203487013
2004
Clark SJ; Millar DS; Molloy P, 2003, 'Bisulfite Methylation Analysis of Tumor Suppressor Genes in Prostate Cancer from Fresh and Archival Tissue Samples', in Prostate Cancer Methods and Protocols, Springer Nature, pp. 219 - 240, http://dx.doi.org/10.1385/1-59259-372-0:219
2003
Journal articles
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Pidsley R; Lam D; Qu W; Peters TJ; Phuc-Loi L; Korbie D; Stirzaker C; Daly RJ; Stricker P; Kench JG; Horvath LG; Clark SJ, 2022, 'Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality', CLINICAL AND TRANSLATIONAL MEDICINE, 12, http://dx.doi.org/10.1002/ctm2.1030
2022
Clark SJ; Molloy PL, 2022, 'Early Insights into Cancer Epigenetics: Gene Promoter Hypermethylation Emerges as a Potential Biomarker for Cancer Detection', Cancer Research, 82, pp. 1461 - 1463, http://dx.doi.org/10.1158/0008-5472.CAN-22-0657
2022
Colino-Sanguino Y; Clark SJ; Valdes-Mora F, 2022, 'Erratum: The H2A.Z-nucleosome code in mammals: emerging functions (Trends in Genetics (2022) 38(3) (273–289), (S0168952521002870), (10.1016/j.tig.2021.10.003)): (Trends in Genetics, 38:3 p:273–289, 2022)', Trends in Genetics, 38, pp. 516, http://dx.doi.org/10.1016/j.tig.2022.02.004
2022
Conduit C; Mak B; Qu W; Lulio JD; Burder R; Bressel M; Cusick T; Dhillon HM; Lourenço RDA; Underhill C; Torres J; Crumbaker M; Honeyball F; Linton A; Allen R; Davis ID; Clark SJ; Horvath LG; Mahon KL, 2022, 'GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)', Therapeutic Advances in Medical Oncology, 14, http://dx.doi.org/10.1177/17588359221092486
2022
Colino-Sanguino Y; Clark SJ; Valdes-Mora F, 2022, 'The H2A.Z-nuclesome code in mammals: emerging functions', Trends in Genetics, 38, pp. 273 - 289, http://dx.doi.org/10.1016/j.tig.2021.10.003
2022
Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, 14, pp. 474 - 474, http://dx.doi.org/10.3390/cancers14030474
2022
Peters TJ; Buckley MJ; Chen Y; Smyth GK; Goodnow CC; Clark SJ, 2021, 'Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate', Nucleic Acids Research, 49, pp. e109, http://dx.doi.org/10.1093/nar/gkab637
2021
Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer GR; Rogers S; Luu PL; Cesare AJ; Clark SJ; Taberlay PC, 2021, 'BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer', Clinical Epigenetics, 13, http://dx.doi.org/10.1186/s13148-021-01023-7
2021
Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109722
2021
Meyer B; Clifton S; Locke W; Luu PL; Du Q; Lam D; Armstrong NJ; Kumar B; Deng N; Harvey K; Swarbrick A; Ganju V; Clark SJ; Pidsley R; Stirzaker C, 2021, 'Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer', Clinical Epigenetics, 13, http://dx.doi.org/10.1186/s13148-021-01210-6
2021
Stirzaker C; Skvortsova K; Clark SJ, 2021, 'Epigenetic changes during tumour development – functional epigenetics study', Pathology, 53, pp. S10 - S11, http://dx.doi.org/10.1016/j.pathol.2021.05.040
2021
Ushijima T; Clark SJ; Tan P, 2021, 'Mapping genomic and epigenomic evolution in cancer ecosystems', Science, 373, pp. 1474 - 1479, http://dx.doi.org/10.1126/science.abh1645
2021
Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 2021, 'Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer', , http://dx.doi.org/10.1101/2021.06.21.449340
2021
Luu PL; Ong PT; Loc TTH; Lam D; Pidsley R; Stirzaker C; Clark SJ, 2021, 'MethPanel: a parallel pipeline and interactive analysis tool for multiplex bisulphite PCR sequencing to assess DNA methylation biomarker panels for disease detection', Bioinformatics, 37, pp. 2198 - 2200, http://dx.doi.org/10.1093/bioinformatics/btaa1060
2021
Schmitz U; Shah JS; Dhungel BP; Monteuuis G; Luu PL; Petrova V; Metierre C; Nair SS; Bailey CG; Saunders VA; Turhan AG; White DL; Branford S; Clark SJ; Hughes TP; Wong JJL; Rasko JEJ, 2020, 'Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients', Cancers, 12, pp. 1 - 19, http://dx.doi.org/10.3390/cancers12123738
2020
Du Q; Smith G; Luu PL; Ferguson J; Armstrong N; Caldon E; Campbell E; Nair S; Zotenko E; Gould C; Buckley M; Kaczorowski D; Barton K; Deveson I; Smith M; Powell J; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark S, 2020, 'DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity', , http://dx.doi.org/10.1101/2020.10.15.338855
2020
Salazar-Roa M; Trakala M; Álvarez-Fernández M; Valdés-Mora F; Zhong C; Muñoz J; Yu Y; Peters TJ; Graña-Castro O; Serrano R; Zapatero-Solana E; Abad M; Bueno MJ; de Cedrón MG; Fernández-Piqueras J; Serrano M; Blasco MA; Wang DZ; Clark SJ; Izpisua-Belmonte JC; Ortega S; Malumbres M, 2020, 'Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells', EMBO Journal, 39, http://dx.doi.org/10.15252/embj.2019104324
2020
Luu PL; Ong PT; Dinh TP; Clark SJ, 2020, 'Benchmark study comparing liftover tools for genome conversion of epigenome sequencing data', NAR Genomics and Bioinformatics, 2, http://dx.doi.org/10.1093/nargab/lqaa054
2020
Lam D; Clark S; Stirzaker C; Pidsley R, 2020, 'Advances in prognostic methylation biomarkers for prostate cancer', Cancers, 12, pp. 1 - 39, http://dx.doi.org/10.3390/cancers12102993
2020
Lam D; Clark S; Stirzaker C; Pidsley R, 2020, 'Advances in Prognostic Methylation Biomarkers for Prostate Cancer', , http://dx.doi.org/10.20944/preprints202010.0154.v1
2020
Green ID; Pinello N; Song R; Lee Q; Halstead JM; Kwok CT; Wong ACH; Nair SS; Clark SJ; Roediger B; Schmitz U; Larance M; Hayashi R; Rasko JEJ; Wong JJL, 2020, 'Macrophage development and activation involve coordinated intron retention in key inflammatory regulators', Nucleic Acids Research, 48, pp. 6513 - 6529, http://dx.doi.org/10.1093/nar/gkaa435
2020
Achinger-Kawecka J; Valdes-Mora F; Luu PL; Giles KA; Caldon CE; Qu W; Nair S; Soto S; Locke WJ; Yeo-Teh NS; Gould CM; Du Q; Smith GC; Ramos IR; Fernandez KF; Hoon DS; Gee JMW; Stirzaker C; Clark SJ, 2020, 'Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-019-14098-x
2020
Khoury A; Achinger-Kawecka J; Bert SA; Smith GC; French HJ; Luu PL; Peters TJ; Du Q; Parry AJ; Valdes-Mora F; Taberlay PC; Stirzaker C; Statham AL; Clark SJ, 2020, 'Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-019-13753-7
2020
Lam D; Luu PL; Song JZ; Qu W; Risbridger GP; Lawrence MG; Lu J; Trau M; Korbie D; Clark SJ; Pidsley R; Stirzaker C, 2020, 'Comprehensive evaluation of targeted multiplex bisulphite PCR sequencing for validation of DNA methylation biomarker panels', Clinical Epigenetics, 12, pp. 90, http://dx.doi.org/10.1186/s13148-020-00880-y
2020
Lawrence MG; Pidsley R; Niranjan B; Papargiris M; Pereira BA; Richards M; Teng L; Norden S; Ryan A; Frydenberg M; Stirzaker C; Taylor RA; Risbridger GP; Clark SJ, 2020, 'Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer', Clinical Epigenetics, 12, pp. 48, http://dx.doi.org/10.1186/s13148-020-00836-2
2020
Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer G; Luu P-L; Cesare AJ; Clark SJ; Taberlay PC, 2020, 'BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells', , http://dx.doi.org/10.1101/2020.07.03.187385
2020
Piggin CL; Roden DL; Law AMK; Molloy MP; Krisp C; Swarbrick A; Naylor MJ; Kalyuga M; Kaplan W; Oakes SR; Gallego-Ortega D; Clark SJ; Carroll JS; Bartonicek N; Ormandy CJ, 2020, 'ELF5 modulates the estrogen receptor cistrome in breast cancer', PLoS Genetics, 16, pp. e1008531, http://dx.doi.org/10.1371/journal.pgen.1008531
2020
Stirzaker C; Skvortsova K; Masle-Farquhar E; Goodnow C; Clark SJ, 2020, 'Epigenetic changes during tumour development – Functional epigenetics study', Pathology, 52, pp. S29 - S29, http://dx.doi.org/10.1016/j.pathol.2020.01.121
2020
Schumann U; Zhang HN; Sibbritt T; Pan A; Horvath A; Gross S; Clark SJ; Yang L; Preiss T, 2020, 'Multiple links between 5-methylcytosine content of mRNA and translation', BMC Biology, 18, http://dx.doi.org/10.1186/s12915-020-00769-5
2020
Du Q; Bert SA; Armstrong NJ; Caldon CE; Song JZ; Nair SS; Gould CM; Luu PL; Peters T; Khoury A; Qu W; Zotenko E; Stirzaker C; Clark SJ, 2019, 'Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer', Nature Communications, 10, pp. 416, http://dx.doi.org/10.1038/s41467-019-08302-1
2019
Peters TJ; French HJ; Bradford ST; Pidsley R; Stirzaker C; Varinli H; Nair S; Qu W; Song J; Giles KA; Statham AL; Speirs H; Speed TP; Clark SJ, 2019, 'Evaluation of cross-platform and interlaboratory concordance via consensus modelling of genomic measurements', Bioinformatics, 35, pp. 560 - 570, http://dx.doi.org/10.1093/bioinformatics/bty675
2019
Mahon KL; Qu W; Lin HM; Spielman C; Cain D; Jacobs C; Stockler MR; Higano CS; de Bono JS; Chi KN; Clark SJ; Horvath LG, 2019, 'Serum Free Methylated Glutathione S-transferase 1 DNA Levels, Survival, and Response to Docetaxel in Metastatic, Castration-resistant Prostate Cancer: Post Hoc Analyses of Data from a Phase 3 Trial', European Urology, 76, pp. 306 - 312, http://dx.doi.org/10.1016/j.eururo.2018.11.001
2019
Salazar-Roa M; Trakala M; Álvarez-Fernández M; Valdés-Mora F; Zhong C; Muñoz J; Yu Y; Peters T; Graña O; Serrano R; Zapatero-Solana E; Abad M; Bueno MJ; de Cedrón MG; Fernández-Piqueras J; Serrano M; Blasco M; Wang D-Z; Clark S; Izpisua-Belmonte JC; Ortega S; Malumbres M, 2019, 'A novel microRNA-based strategy to expand the differentiation potency of stem cells', , http://dx.doi.org/10.1101/826446
2019
Colino-Sanguino Y; Cornett EM; Moulder D; Smith GC; Hrit J; Cordeiro-Spinetti E; Vaughan RM; Krajewski K; Rothbart SB; Clark SJ; Valdés-Mora F, 2019, 'A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation', iScience, 21, pp. 773 - 788, http://dx.doi.org/10.1016/j.isci.2019.10.053
2019
Bradford ST; Nair SS; Statham AL; van Dijk SJ; Peters TJ; Anwar F; French HJ; von Martels JZH; Sutcliffe B; Maddugoda MP; Peranec M; Varinli H; Arnoldy R; Buckley M; Ross JP; Zotenko E; Song JZ; Stirzaker C; Bauer DC; Qu W; Swarbrick MM; Lutgers HL; Lord RV; Samaras K; Molloy PL; Clark SJ, 2019, 'Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes', Scientific Reports, 9, pp. 9511, http://dx.doi.org/10.1038/s41598-019-45777-w
2019
Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004
2019
Giles KA; Gould CM; Du Q; Skvortsova K; Song JZ; Maddugoda MP; Achinger-Kawecka J; Stirzaker C; Clark SJ; Taberlay PC, 2019, 'Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups', Epigenetics and Chromatin, 12, pp. 12, http://dx.doi.org/10.1186/s13072-019-0258-9
2019
Milevskiy MJG; Gujral U; Del Lama Marques C; Stone A; Northwood K; Burke LJ; Gee JMW; Nephew K; Clark S; Brown MA, 2019, 'MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer', British Journal of Cancer, 120, pp. 621 - 632, http://dx.doi.org/10.1038/s41416-019-0395-8
2019
Tarr IS; McCann EP; Benyamin B; Peters TJ; Twine NA; Zhang KY; Zhao Q; Zhang ZH; Rowe DB; Nicholson GA; Bauer D; Clark SJ; Blair IP; Williams KL, 2019, 'Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-44765-4
2019
Nair SS; Luu PL; Qu W; Maddugoda M; Huschtscha L; Reddel R; Chenevix-Trench G; Toso M; Kench JG; Horvath LG; Hayes VM; Stricker PD; Hughes TP; White DL; Rasko JEJ; Wong JJL; Clark SJ, 2018, 'Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten', Epigenetics and Chromatin, 11, http://dx.doi.org/10.1186/s13072-018-0194-0
2018
Stirzaker C; Song JZ; Statham AL; Clark SJ, 2018, 'Bisulphite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq)', Methods in Molecular Biology, 1708, pp. 285 - 302, http://dx.doi.org/10.1007/978-1-4939-7481-8_15
2018
Holliday H; Baker LA; Junankar SR; Clark SJ; Swarbrick A, 2018, 'Epigenomics of mammary gland development', Breast Cancer Research, 20, http://dx.doi.org/10.1186/s13058-018-1031-x
2018
Carpenter BL; Zhou W; Madaj Z; DeWitt AK; Ross JP; Grønbæk K; Liang G; Clark SJ; Molloy PL; Jones PA, 2018, 'Mother–child transmission of epigenetic information by tunable polymorphic imprinting', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. E11970 - E11977, http://dx.doi.org/10.1073/pnas.1815005115
2018
Pidsley R; Lawrence MG; Zotenko E; Niranjan B; Statham A; Song J; Chabanon RM; Qu W; Wang H; Richards M; Nair SS; Armstrong NJ; Nim HT; Papargiris M; Balanathan P; French H; Peters T; Norden S; Ryan A; Pedersen J; Kench J; Daly RJ; Horvath LG; Stricker P; Frydenberg M; Taylor RA; Stirzaker C; Risbridger GP; Clark SJ, 2018, 'Enduring epigenetic landmarks define the cancer microenvironment', Genome Research, 28, pp. 625 - 638, http://dx.doi.org/10.1101/gr.229070.117
2018
O'Donoghue SI; Baldi BF; Clark SJ; Darling AE; Hogan JM; Kaur S; Maier-Hein L; McCarthy DJ; Moore WJ; Stenau E; Swedlow JR; Vuong J; Procter JB, 2018, 'Visualization of Biomedical Data', ANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE, VOL 1, 1, pp. 275 - 304, http://dx.doi.org/10.1146/annurev-biodatasci-080917-013424
2018
Lawrence M; Pidlsey R; Zotenko E; Niranjan B; Nair S; French H; Statham A; Song J; Chabanon R; Papargiris M; Ellem S; Frydenberg M; Pedersen J; Stirzaker C; Taylor R; Clark S; Risbridger G, 2017, 'Hypomethylation of estrogen receptor alpha: a landmark in the epigenome landscape of prostate cancer stroma', CLINICAL ENDOCRINOLOGY, 86, pp. 23 - 23, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000393453600061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Knaupp AS; Buckberry S; Pflueger J; Lim SM; Ford E; Larcombe MR; Rossello FJ; de Mendoza A; Alaei S; Firas J; Holmes ML; Nair SS; Clark SJ; Nefzger CM; Lister R; Polo JM, 2017, 'Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming', Cell Stem Cell, 21, pp. 834 - 845.e6, http://dx.doi.org/10.1016/j.stem.2017.11.007
2017
Stirzaker C; Song JZ; Ng W; Du Q; Armstrong NJ; Locke WJ; Statham AL; French H; Pidsley R; Valdes-Mora F; Zotenko E; Clark SJ, 2017, 'Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer', Oncogene, 36, pp. 1328 - 1338, http://dx.doi.org/10.1038/onc.2016.297
2017
Valdés-Mora F; Gould CM; Colino-Sanguino Y; Qu W; Song JZ; Taylor KM; Buske FA; Statham AL; Nair SS; Armstrong NJ; Kench JG; Lee KML; Horvath LG; Qiu M; Ilinykh A; Yeo-Teh NS; Gallego-Ortega D; Stirzaker C; Clark SJ, 2017, 'Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-01393-8
2017
Achinger-Kawecka J; Clark SJ, 2017, 'Disruption of the 3D cancer genome blueprint', Epigenomics, 9, pp. 47 - 55, http://dx.doi.org/10.2217/epi-2016-0111
2017
Skvortsova K; Zotenko E; Luu PL; Gould CM; Nair SS; Clark SJ; Stirzaker C, 2017, 'Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA', Epigenetics and Chromatin, 10, http://dx.doi.org/10.1186/s13072-017-0123-7
2017
Mahon KL; Qu W; Lin H-M; Spielman C; Cain D; Jacobs C; Chi KN; De Bono JS; Higano CS; Clark SJ; Horvath L, 2017, 'Post hoc analysis of a phase III study to test the association between circulating methylated glutathione s transferase (mGSTP1) DNA levels and response to docetaxel (DTX) in metastatic castration resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, 35, pp. 5014 - 5014, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5014
2017
Clark SJ; Molloy PL, 2017, 'Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation', Cancer Cell, 32, pp. 278 - 280, http://dx.doi.org/10.1016/j.ccell.2017.08.016
2017
Pidsley R; Zotenko E; Peters TJ; Lawrence MG; Risbridger GP; Molloy P; Van Djik S; Muhlhausler B; Stirzaker C; Clark SJ, 2016, 'Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling', GENOME BIOLOGY, 17, http://dx.doi.org/10.1186/s13059-016-1066-1
2016
Hou L; Heilbronner U; Degenhardt F; Adli M; Akiyama K; Akula N; Ardau R; Arias B; Backlund L; Banzato CEM; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Brichant-Petitjean C; Bui ET; Cervantes P; Chen GB; Chen HC; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Étain B; Falkai P; Forstner AJ; Frisén L; Fullerton JM; Gard S; Garnham JS; Goes FS; Grof P; Gruber O; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jiménez E; Kahn JP; Kassem L; Kittel-Schneider S; Kliwicki S; König B; Kusumi I; Lackner N; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Jaramillo CAL; Macqueen G; Manchia M; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Ösby U; Ozaki N; Perlis RH; Pfennig A; Reich-Erkelenz D; Rouleau GA; Schofield PR; Schubert KO; Schweizer BW; Seemüller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Smoller JW; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Volkert J; Witt S; Wright A; Young LT; Zandi PP; Potash JB; Depaulo JR, 2016, 'Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study', The Lancet, 387, pp. 1085 - 1093, http://dx.doi.org/10.1016/S0140-6736(16)00143-4
2016
Taberlay PC; Achinger-Kawecka J; Lun ATL; Buske FA; Sabir KS; Gould CM; Zotenko E; Bert SA; Giles KA; Bauer D; Smyth GK; Stirzaker C; O Donoghue SI; Clark SJ, 2016, 'Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations', Genome Research, 26, pp. 719 - 731, http://dx.doi.org/10.1101/gr.201517.115
2016
Pidsley R; Zotenko E; Peters TJ; Lawrence MG; Risbridger GP; Molloy P; Van Djik S; Muhlhausler B; Stirzaker C; Clark SJ, 2016, 'Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling', Genome Biology, 17, http://dx.doi.org/10.1186/s13059-016-1066-1
2016
Bock C; Halbritter F; Carmona FJ; Tierling S; Datlinger P; Assenov Y; Berdasco M; Bergmann AK; Booher K; Busato F; Campan M; Dahl C; Dahmcke CM; Diep D; Fernández AF; Gerhauser C; Haake A; Heilmann K; Holcomb T; Hussmann D; Ito M; Kläver R; Kreutz M; Kulis M; Lopez V; Nair SS; Paul DS; Plongthongkum N; Qu W; Queirós AC; Reinicke F; Sauter G; Schlomm T; Statham A; Stirzaker C; Strogantsev R; Urdinguio RG; Walter K; Weichenhan D; Weisenberger DJ; Beck S; Clark SJ; Esteller M; Ferguson-Smith AC; Fraga MF; Guldberg P; Hansen LL; Laird PW; Martín-Subero JI; Nygren AOH; Peist R; Plass C; Shames DS; Siebert R; Sun X; Tost J; Walter J; Zhang K, 2016, 'Quantitative comparison of DNA methylation assays for biomarker development and clinical applications', Nature Biotechnology, 34, pp. 726 - 737, http://dx.doi.org/10.1038/nbt.3605
2016
Achinger-Kawecka J; Taberlay PC; Clark SJ, 2016, 'Alterations in three-dimensional organization of the cancer genome and epigenome', Cold Spring Harbor Symposia on Quantitative Biology, 81, pp. 41 - 51, http://dx.doi.org/10.1101/sqb.2016.81.031013
2016
Walton SJ; Lewis A; Jeffery R; Thompson H; Feakins R; Giannoulatou E; Yau C; Lindsay JO; Clark SK; Silver A, 2016, 'Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours', Oncoscience, 3, pp. 173 - 185, http://dx.doi.org/10.18632/oncoscience.312
2016
Lim AM; Wong NC; Pidsley R; Zotenko E; Corry J; Dobrovic A; Clark SJ; Rischin D; Solomon B, 2016, 'Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas', Clinical Epigenetics, 8, http://dx.doi.org/10.1186/s13148-016-0235-0
2016
Colino-Sanguino Y; Clark SJ; Valdes-Mora F, 2016, 'H2A.Z acetylation and transcription: Ready, steady, go!', Epigenomics, 8, pp. 583 - 586, http://dx.doi.org/10.2217/epi-2016-0016
2016
Mathe A; Wong-Brown M; Locke WJ; Stirzaker C; Braye SG; Forbes JF; Clark SJ; Avery-Kiejda KA; Scott RJ, 2016, 'DNA methylation profile of triple negative breast cancer-specific genes comparing lymph node positive patients to lymph node negative patients', Scientific Reports, 6, http://dx.doi.org/10.1038/srep33435
2016
Stirzaker C; Zotenko E; Clark SJ, 2016, 'Genome-wide DNA methylation profiling in triple-negative breast cancer reveals epigenetic signatures with important clinical value', Molecular and Cellular Oncology, 3, http://dx.doi.org/10.1080/23723556.2015.1038424
2016
Milevskiy MJG; Al-Ejeh F; Saunus JM; Northwood KS; Bailey PJ; Betts JA; Reed AEMC; Nephew KP; Stone A; Gee JMW; Dowhan DH; Dray E; Shewan AM; French JD; Edwards SL; Clark SJ; Lakhani SR; Brown MA, 2016, 'Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer', Human Molecular Genetics, 25, pp. 3269 - 3283, http://dx.doi.org/10.1093/hmg/ddw177
2016
Peters TJ; Buckley MJ; Statham AL; Pidsley R; Samaras K; V Lord R; Clark SJ; Molloy PL, 2015, 'De novo identification of differentially methylated regions in the human genome', Epigenetics and Chromatin, 8, http://dx.doi.org/10.1186/1756-8935-8-6
2015
Van Dijk SJ; Molloy PL; Varinli H; Morrison JL; Muhlhausler BS; Buckley M; Clark SJ; McMillen IC; Noakes M; Samaras K; Tellam RL, 2015, 'Epigenetics and human obesity', International Journal of Obesity, 39, pp. 85 - 97, http://dx.doi.org/10.1038/ijo.2014.34
2015
Valdés-Mora F; Clark SJ, 2015, 'Prostate cancer epigenetic biomarkers: next-generation technologies', Oncogene, 34, pp. 1609 - 1618, http://dx.doi.org/10.1038/onc.2014.111
2015
Phua YW; Nguyen A; Roden DL; Elsworth B; Deng N; Nikolic I; Yang J; Mcfarland A; Russell R; Kaplan W; Cowley MJ; Nair R; Zotenko E; O'Toole S; Tan SX; James DE; Clark SJ; Kouros-Mehr H; Swarbrick A, 2015, 'MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene', Breast Cancer Research, 17, http://dx.doi.org/10.1186/s13058-015-0593-0
2015
Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330
2015
Stirzaker C; Zotenko E; Song JZ; Qu W; Nair SS; Locke WJ; Stone A; Armstong NJ; Robinson MD; Dobrovic A; Avery-Kiejda KA; Peters KM; French JD; Stein S; Korbie DJ; Trau M; Forbes JF; Scott RJ; Brown MA; Francis GD; Clark SJ, 2015, 'Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value', Nature Communications, 6, pp. 5899 - 5899, http://dx.doi.org/10.1038/ncomms6899
2015
Stone A; Zotenko E; Locke WJ; Korbie D; Millar EKA; Pidsley R; Stirzaker C; Graham P; Trau M; Musgrove EA; Nicholson RI; Gee JMW; Clark SJ, 2015, 'DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8758
2015
Statham AL; Taberlay PC; Kelly TK; Jones PA; Clark SJ, 2015, 'Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines', Genomics Data, 3, pp. 94 - 96, http://dx.doi.org/10.1016/j.gdata.2014.11.012
2015
Varinli H; Statham AL; Clark SJ; Molloy PL; Ross JP, 2015, 'COBRA-seq: Sensitive and quantitative methylome profiling', Genes, 6, pp. 1140 - 1163, http://dx.doi.org/10.3390/genes6041140
2015
Locke WJ; Zotenko E; Stirzaker C; Robinson MD; Hinshelwood RA; Stone A; Reddel RR; Huschtscha LI; Clark SJ, 2015, 'Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis', Clinical Epigenetics, 7, http://dx.doi.org/10.1186/s13148-015-0086-0
2015
Korbie D; Lin E; Wall D; Nair SS; Stirzaker C; Clark SJ; Trau M, 2015, 'Multiplex bisulfite PCR resequencing of clinical FFPE DNA', Clinical Epigenetics, 7, http://dx.doi.org/10.1186/s13148-015-0067-3
2015
Du Q; Luu PL; Stirzaker C; Clark SJ, 2015, 'Methyl-CpG-binding domain proteins: Readers of the epigenome', Epigenomics, 7, pp. 1051 - 1073, http://dx.doi.org/10.2217/epi.15.39
2015
Clark S; Sarlin P; Sharma A; Sisson SA, 2015, 'Increasing dependence on foreign water resources? An assessment of trends in global virtual water flows using a self-organizing time map', Ecological Informatics, 26, pp. 192 - 202, http://dx.doi.org/10.1016/j.ecoinf.2014.05.012
2015
Lawrence M; Pidsley R; Ellem S; Furic L; Nair S; French H; Stratham A; Larsson O; Frydenberg M; Pedersen J; Buchanan G; Taylor R; Clark S; Risbridger G, 2015, 'Oestrogen receptor α promotes prostate cancer progression through dual actions in both epithelia and stroma', Endocrine Abstracts, http://dx.doi.org/10.1530/endoabs.37.oc8.5
2015
Clark S; Sisson SA; Sharma A, 2014, 'A dimension range representation (DRR) measure for self-organizing maps', Pattern Recognition, http://dx.doi.org/10.1016/j.patcog.2015.11.002
2014
Ali NA; Wu J; Hochgräfe F; Chan H; Nair R; Ye S; Zhang L; Lyons RJ; Pinese M; Lee HC; Armstrong N; Ormandy CJ; Clark SJ; Swarbrick A; Daly RJ, 2014, 'Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways', Breast Cancer Research, 16, http://dx.doi.org/10.1186/s13058-014-0437-3
2014
Taberlay PC; Statham AL; Kelly TK; Clark SJ; Jones PA, 2014, 'Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer', Genome Research, 24, pp. 1421 - 1432, http://dx.doi.org/10.1101/gr.163485.113
2014
Warton K; Lin V; Navin T; Armstrong NJ; Kaplan W; Ying K; Gloss B; Mangs H; Nair SS; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2014, 'Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma', BMC Genomics, 15, http://dx.doi.org/10.1186/1471-2164-15-476
2014
Buske FA; French HJ; Smith MA; Clark SJ; Bauer DC, 2014, 'NGSANE: a lightweight production informatics framework for high-throughput data analysis', Bioinformatics, 30, pp. 1471 - 1472, http://dx.doi.org/10.1093/bioinformatics/btu036
2014
Lin HM; Castillo L; Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler MR; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark SJ; Swarbrick A; Daly RJ; Horvath LG, 2014, 'Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer', British Journal of Cancer, 110, pp. 2462 - 2471, http://dx.doi.org/10.1038/bjc.2014.181
2014
Riebler A; Menigatti M; Song JZ; Statham AL; Stirzaker C; Mahmud N; Mein CA; Clark SJ; Robinson MD, 2014, 'BayMeth:Improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach', Genome Biology, 15, http://dx.doi.org/10.1186/gb-2014-15-2-r35
2014
Gloss B; Moran-Jones K; Lin V; Gonzalez M; Scurry J; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2014, 'ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer', Molecular Cancer, 13, http://dx.doi.org/10.1186/1476-4598-13-3
2014
Mahon KL; Qu W; Devaney J; Paul C; Castillo L; Wykes RJ; Chatfield MD; Boyer MJ; Stockler MR; Marx G; Gurney H; Mallesara G; Molloy PL; Horvath LG; Clark SJ, 2014, 'Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer', British Journal of Cancer, 111, pp. 1802 - 1809, http://dx.doi.org/10.1038/bjc.2014.463
2014
Stirzaker C; Taberlay PC; Statham AL; Clark SJ, 2014, 'Mining cancer methylomes: Prospects and challenges', Trends in Genetics, 30, pp. 75 - 84, http://dx.doi.org/10.1016/j.tig.2013.11.004
2014
Skulte KA; Phan L; Clark SJ; Taberlay PC, 2014, 'Chromatin remodeler mutations in human cancers: Epigenetic implications', Epigenomics, 6, pp. 397 - 414, http://dx.doi.org/10.2217/epi.14.37
2014
Stone A; Cowley MJ; Valdes-Mora F; McCloy RA; Sergio CM; Gallego-Ortega D; Caldon CE; Ormandy CJ; Biankin AV; Gee JMW; Nicholson RI; Print CG; Clark SJ; Musgrove EA, 2013, 'BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer', Molecular Cancer Therapeutics, 12, pp. 1874 - 1885, http://dx.doi.org/10.1158/1535-7163.MCT-13-0012
2013
Stone A; Valdes-Mora F; Clark SJ, 2013, 'Exploring and exploiting the aberrant DNA methylation profile of endocrine-resistant breast cancer', Epigenomics, 5, pp. 595 - 598, http://dx.doi.org/10.2217/epi.13.70
2013
Hulf T; Sibbritt T; Wiklund ED; Patterson K; Song JZ; Stirzaker C; Qu W; Nair S; Horvath LG; Armstrong NJ; Kench JG; Sutherland RL; Clark SJ, 2013, 'Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer', Oncogene, 32, pp. 2891 - 2899, http://dx.doi.org/10.1038/onc.2012.300
2013
Clark AK; Taubenberger AV; Taylor RA; Niranjan B; Chea ZY; Zotenko E; Sieh S; Pedersen JS; Norden S; Frydenberg M; Grummet JP; Pook DW; Stirzaker C; Clark SJ; Lawrence MG; Ellem SJ; Hutmacher DW; Risbridger GP, 2013, 'A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer', Biomaterials, 34, pp. 4777 - 4785, http://dx.doi.org/10.1016/j.biomaterials.2013.03.005
2013
Bert SA; Robinson MD; Strbenac D; Statham AL; Song JZ; Hulf T; Sutherland RL; Coolen MW; Stirzaker C; Clark SJ, 2013, 'Regional Activation of the Cancer Genome by Long-Range Epigenetic Remodeling', Cancer Cell, 23, pp. 9 - 22, http://dx.doi.org/10.1016/j.ccr.2012.11.006
2013
Warton K; Vita L; Armstrong NJ; Kaplan W; Ying K; Mangs H; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2013, 'Whole genome sequencing of free circulating DNA from plasma of HGSOC patients', CLINICAL CANCER RESEARCH, 19, http://dx.doi.org/10.1158/1078-0432.OVCA13-A4
2013
Kalyuga M; Gallego-Ortega D; Lee H; Roden DL; Cowley MJ; Caldon CE; Stone A; Allerdice SL; Valdes-Mora F; Rosalind launchbury R; Statham A; Armstrong NJ; Alles MC; Adelaide young A; Egger A; Au W; Piggin CL; Evans C; Ledger A; Brummer T; Oakes SR; Kaplan W; Gee JMW; Robert i nicholson RI; Sutherland RL; Swarbrick A; Naylor MJ; Clark SJ; Carroll JS; Ormandy CJ, 2012, 'ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer', PLoS Biology, 10, pp. e1001461, http://dx.doi.org/10.1371/journal.pbio.1001461
2012
Valdes-Mora F; Song JZ; Statham AL; Strbenac D; Robinson MD; Nair SS; Patterson K; Tremethick DJ; Stirzaker C; Clark SJ, 2012, 'Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer', Genome Research, 22, pp. 307 - 321, http://dx.doi.org/10.1101/gr.118919.110
2012
Wee EJH; Peters K; Nair SS; Hulf T; Stein S; Wagner S; Bailey PJ; Lee SY; Qu WJ; Brewster B; French JD; Dobrovic A; Francis GD; Clark SJ; Brown MA, 2012, 'Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer', Oncogene, 31, pp. 4182 - 4195, http://dx.doi.org/10.1038/onc.2011.584
2012
Peters K; Edwards S; Nair SS; French J; Bailey PJ; Salkield K; Stein SR; Wagner S; Francis G; Clark SJ; Brown M, 2012, 'Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events', BMC Cancer, 12, pp. 132, http://dx.doi.org/10.1186/1471-2407-12-132
2012
Gloss B; Patterson K; Barton CA; Gonzalez M; Scurry JP; Hacker NF; Sutherland RL; O''brien P; Clark SJ, 2012, 'Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers', Cancer Letters, 318, pp. 76 - 85, http://dx.doi.org/10.1016/j.canlet.2011.12.003
2012
Robinson MD; Strbenac D; Stirzaker C; Statham A; Song JZ; Speed TP; Clark SJ, 2012, 'Copy-number-aware differential analysis of quantitative DNA sequencing data', Genome Research, 22, pp. 2490 - 2496, http://dx.doi.org/10.1101/gr.139055.112
2012
Beck S; Bernstein BE; Campbell RM; Costello JF; Dhanak D; Ecker JR; Greally JM; Issa JP; Laird PW; Polyak K; Tycko B; Jones PA; Force ACET, 2012, 'A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force', Cancer Res, 72, pp. 6319 - 6324, http://dx.doi.org/10.1158/0008-5472.CAN-12-3658
2012
Mayor R; Munoz M; Coolen MW; Custodio J; Esteller M; Clark SJ; Peinado M, 2011, 'Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells', Epigenetics, 6, pp. 1138 - 1148, http://dx.doi.org/10.4161/epi.6.9.16066
2011
Robinson MD; Stirzaker C; Statham AL; Coolen MW; Song JZ; Nair SS; Strbenac D; Speed TP; Clark SJ, 2011, 'Evaluation of affinity-based genome-wide DNA methylation data: Effects of CpG density, amplification bias, and copy number variation (Genome Research (2010), 20 (1719-1729))', Genome Research, 21, pp. 146
2011
Horvath L; Mahon KL; Qu W; Devaney J; Chatfield MD; Paul C; Wykes R; Boyer MJ; Stockler MR; Marx GM; Sutherland RL; Clark SJ, 2011, 'A study of methylated glutathione s-transferase 1 (mGSTP1)as a potential plasma epigenetic marker of response to chemotherapy and prognosis in men with castration-resistant prostate cancer (CRPC).', J Clin Oncol, 29, pp. 4603, http://www.ncbi.nlm.nih.gov/pubmed/28024014
2011
Patterson K; Molloy L; Qu W; Clark S, 2011, 'DNA methylation: bisulphite modification and analysis.', Journal of visualized experiments : JoVE
2011
Braithwaite J; Westbrook J; Johnston BW; Clarke S; Brandon M; Banks M; Hughes C; Greenfield DR; Pawsey M; Corbett AD; Georgiou A; Callen J; Ovreveit J; Pope C; Suñol R; Shaw C; Debono DS; Westbrook MT; Hinchcliff R; Moldovan M, 2011, 'Strengthening organizational performance through accreditation research - a framework for twelve interrelated studies: the ACCREDIT project study protocol', BMC Research Notes, 4, pp. 390 - 399, http://dx.doi.org/10.1186/1756-0500-4-390
2011
Coolen MW; Statham A; Qu W; Campbell M; Henders AK; Montgomery GW; Martin N; Clark SJ, 2011, 'Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins', PLoS One, 6, pp. e25590, http://dx.doi.org/10.1371/journal.pone.0025590
2011
Hulf T; Sibbritt T; Wikland K; Bert S; Strbenac D; Statham AL; Robinson M; Clark SJ, 2011, 'Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription', BMC Genomics, 12, pp. 54 - 64, http://dx.doi.org/10.1186/1471-2164-12-54
2011
Lee HJ; Hinshelwood R; Bouras T; Gallego-Ortega D; Valdes-Mora F; Blazek K; Visvader JE; Clark SJ; Ormandy CJ, 2011, 'Lineage specific methylation of the Elf5 promoter in mammary epithelial cells', Stem Cells, 29, pp. 1611 - 1619, http://dx.doi.org/10.1002/stem.706
2011
Hansen TK; Wiklund ED; Bramsen J; Villadsen S; Statham AL; Clark SJ; Kjems J, 2011, 'miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA', European Molecular Biology Organization, 30, pp. 4414 - 4422, http://dx.doi.org/10.1038/emboj.2011.359
2011
Nair SS; Coolen MW; Stirzaker C; Song J; Statham AL; Strbenac D; Robinson MR; Clark SJ, 2011, 'Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias', Epigenetics, 6, pp. 34 - 44, http://dx.doi.org/10.4161/epi.6.1.13313
2011
Wikland E; Bramsen J; Hulf T; Dyrskjot L; Ramanathan P; Hansen TK; Villadsen S; Gao SJ; Ostenfeld MS; Borre M; Peters M; Ortntoft T; Kjems J; Clark SJ, 2011, 'Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer', International Journal of Cancer, 128, pp. 1327 - 1334, http://dx.doi.org/10.1002/ijc.25461
2011
Jeronimo C; Bastian PJ; Bjartell A; Carbone GM; Catto JWF; Clark SJ; Henrique R; Nelson WG; Shariat SF, 2011, 'Epigenetics in prostate cancer: Biologic and clinical relevance', European Urology, 60, pp. 753 - 766, http://dx.doi.org/10.1016/j.eururo.2011.06.035
2011
Patterson K; Molloy L; Qu W; Clark S, 2011, 'DNA methylation: Bisulphite modification and analysis', Journal of Visualized Experiments, http://dx.doi.org/10.3791/3170
2011
Devaney J; Stirzaker C; Qu W; Song JZ; Statham AL; Patterson K; Horvath LG; Tabor B; Coolen MW; Hulf T; Kench JG; Henshall SM; Pe benito R; Haynes AM; Mayor R; Peinado M; Sutherland RL; Clark SJ, 2011, 'Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers', Cancer Epidemiology Biomarkers and Prevention, 20, pp. 148 - 159, http://dx.doi.org/10.1158/1055-9965.EPI-10-0719
2011
Wikland E; Gao SJ; Hulf T; Sibbritt T; Nair SS; Costea A; Villadsen S; Bakholdt V; Bramsen J; Sorensen J; Krogdahl A; Clark SJ; Kjems J, 2011, 'MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma', PLoS One, 6, pp. e27840 - e27851, http://dx.doi.org/10.1371/journal.pone.0027840
2011
Barton CA; Gloss B; Qu W; Statham AL; Hacker NF; Sutherland RL; Clark SJ; O Brien P, 2010, 'Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival', British Journal of Cancer, 102, pp. 87 - 96, http://dx.doi.org/10.1038/sj.bjc.6605429
2010
Wiklund ED; Kjems J; Clark SJ, 2010, 'Epigenetic architecture and miRNA: Reciprocal regulators', Epigenomics, 2, pp. 823 - 840, http://dx.doi.org/10.2217/epi.10.51
2010
Robinson M; Statham AL; Speed TP; Clark SJ, 2010, 'Protocol matters: Which methylome are you actually studying?', Epigenomics, 2, pp. 587 - 598, http://dx.doi.org/10.2217/epi.10.36
2010
Robinson M; Stirzaker C; Statham AL; Coolen M; Song J; Nair S; Strbenac D; Speed TP; Clark SJ, 2010, 'Evaluation of affinity-based genome-wide DNA methylation data: Effects of CpG density, amplification bias, and copy number variation', Genome Research, 20, pp. 1719 - 1729, http://dx.doi.org/10.1101/gr.110601.110
2010
Statham AL; Strbenac D; Coolen M; Stirzaker C; Robinson M; Clark SJ, 2010, 'Repitools: an R package for the analysis of enrichment-based epigenomic data', Bioinformatics, 26, pp. 1662 - 1663, http://dx.doi.org/10.1093/bioinformatics/btq247
2010
Coolen M; Stirzaker C; Song JZ; Statham AL; Kassir Z; Moreno CS; Young AM; Varma V; Speed TP; Cowley MJ; Lacaze P; Kaplan W; Robinson M; Clark SJ, 2010, 'Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity', Nature Cell Biology, 12, pp. 235 - 246, http://dx.doi.org/10.1038/ncb2023
2010
Kjems J; Wiklund ED; Bramsen JB; Hulf T; Dyrskjot L; Clark SJ, 2010, 'Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer', NEW BIOTECHNOLOGY, 27, pp. S7 - S8, http://dx.doi.org/10.1016/j.nbt.2010.01.303
2010
Mayor R; Casadome L; Azuara D; Moreno V; Clark SJ; Capella G; Peinado M, 2009, 'Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease', British Journal of Cancer, 100, pp. 1534 - 1539, http://dx.doi.org/10.1038/sj.bjc.6605045
2009
McCormack A; McDonald K; Gill A; Clark SJ; Burt MG; Campbell K; Braund W; Little N; Cook R; Grossman AB; Robinson BG; Clifton-Bligh R, 2009, 'Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours', Clinical Endocrinology, 71, pp. 226 - 233, http://dx.doi.org/10.1111/j.1365-2265.2008.03487.x
2009
Hinshelwood R; Melki J; Huschtscha L; Paul C; Song JZ; Stirzaker C; Reddel RR; Clark SJ, 2009, 'Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning', Human Molecular Genetics, 18, pp. 3098 - 3109, http://dx.doi.org/10.1093/hmg/ddp251
2009
Hynd PI; Edwards NM; Hebart M; McDowall M; Clark S, 2009, 'Wool fibre crimp is determined by mitotic asymmetry and position of final keratinisation and not ortho- and para-cortical cell segmentation', Animal, 3, pp. 838 - 843, http://dx.doi.org/10.1017/S1751731109003966
2009
jones PD; Archer T; Baylin S; Beck S; Berger SM; Bernstein B; Carpten J; Clark SJ; Costello J; Doerge R; Esteller M; Feinberg A; Gingeras T; Greally J; Henikoff S; Herman J; Jackson-Grusby L; Jenuwein T; Jirtle R; Lim B; Laird P; Lim B; Martienssen R; Polyak K; Stunnenberg H; Tlsty T; Tycko B; Ushijima T; Zhu J; Pirrotta V; Allis C; Elgin S; Rine J; Wu C, 2008, 'Moving AHEAD with an international human epigenome project', Nature, 454, pp. 711 - 715, http://dx.doi.org/10.1038/454711a
2008
Barton CA; Hacker NF; Clark SJ; O Brien P, 2008, 'DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment', Gynecologic Oncology, 109, pp. 129 - 139, http://dx.doi.org/10.1016/j.ygyno.2007.12.017
2008
Barton CA; Clark SJ; Hacker NF; O Brien P, 2008, 'Epigenetic markers of ovarian cancer', Advances in Experimental Medicine and Biology, 622, pp. 35 - 51, http://dx.doi.org/10.1007/978-0-387-68969-2_4
2008
Guerrero-Bosagna CM; Sabat P; Valdovinos FS; Valladares LE; Clark SJ, 2008, 'Epigenetic and phenotypic changes result from a continuous pre and post dietary exposure to phytoestrogens in an experimental population of mice', BMC Physiology, 8, pp. 1 - 19, http://dx.doi.org/10.1186/1472-6793-8-17
2008
Hinshelwood R; Clark SJ, 2008, 'Breast cancer epigenetics: normal human mammary epithelial cells as a model system', Journal of Molecular Medicine - Jmm, 86, pp. 1315 - 1328, http://dx.doi.org/10.1007/s00109-008-0386-3
2008
Coolen M; Statham A; Gardiner-Garden M; Clark SJ, 2007, 'Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements', Nucleic Acids Research, 35, http://dx.doi.org/10.1093/nar/gkm662
2007
Hinshelwood R; Huschtscha L; Melki J; Stirzaker C; Abdipranoto A; Vissel B; Ravasi T; Wells C; Hume DP; Reddel R; Clark SJ, 2007, 'Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis', Cancer research, 67, pp. 11517 - 11527, http://dx.doi.org/10.1158/0008-5472.CAN-07-1284
2007
Hitchins MP; Ap Lin V; Buckle AD; Cheong KF; Halani N; Ku S; Kwok C; Packham D; Suter CM; Meagher AP; Stirzaker C; Clark SJ; Hawkins NJ; Ward RL, 2007, 'Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer', Cancer research, 67, pp. 9107 - 9116, http://dx.doi.org/10.1158/0008-5472.CAN-07-0869
2007
Clark SJ, 2007, 'Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis', Human Molecular Genetics, 16, pp. R88 - R95, http://dx.doi.org/10.1093/hmg/ddm051
2007
Frigola J; Song J; Stirzaker C; Hinshelwood R; Peinado M; Clark SJ, 2006, 'Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band', Nature Genetics, 38, pp. 540 - 549, http://dx.doi.org/10.1038/ng1781
2006
Wong NC; Wong LH; Quach JM; Canham P; Craig JM; Song JZ; Clark SJ; Choo KHA, 2006, 'Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation', PLoS Genetics, 2, pp. 172 - 186, http://dx.doi.org/10.1179/146531205225021589
2006
Rand KN; Mitchell SM; Clark SJ; Molloy PL, 2006, 'Bisulphite differential denaturation PCR for analysis of DNA methylation', Epigenetics, 1, pp. 94 - 100, http://dx.doi.org/10.4161/epi.1.2.2680
2006
Wen VW; Wu K; Baksh S; Hinselwood RA; Lock RB; Clark SJ; Moore MA; Mackenzie K, 2006, 'Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53 competent immortal endothelial cells', Cancer research, 66, pp. 10691 - 10700, http://dx.doi.org/10.1158/0008-5472.CAN-06-0979
2006
Clark SJ; Statham A; Stirzaker C; Molloy PL; Frommer M, 2006, 'DNA methylation: Bisulphite modification and analysis', Nature Protocols, 1, pp. 2353 - 2364, http://dx.doi.org/10.1038/nprot.2006.324
2006
Rand KN; Ho T; Qu W; Mitchell SM; White R; Clark SJ; Molloy PL, 2005, 'Headloop suppression PCR and its application to selective amplification of methylated DNA sequences', Nucleic Acids Research, 33, pp. 1 - 11, http://dx.doi.org/10.1093/nar/gni120
2005
Broad A; Links MR; Rosenthal M; Abraham R; Clark SJ; Burns I; Dilulio J; Mitchell P, 2005, 'Oxaliplatin and gemcitabine in advanced NSCLC: A multicentre phase 2 Australian study', Lung Cancer, 49, pp. S239 - S239
2005
Wong NC-L; Wong LH; Quach JM; Canham P; Craig JM; Song JZ; Clark SJ; Choo A, 2005, 'Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation', PLoS Genetics, preprint, pp. e17 - e17, http://dx.doi.org/10.1371/journal.pgen.0020017.eor
2005
Frigola J; Munoz MA; Clark SJ; Moreno V; Capella G; Peinado M, 2005, 'Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy', Oncogene, 24, pp. 7320 - 7326, http://dx.doi.org/10.1038/sj.onc.1208883
2005
Rand KN; Ho T; Qu W; Mitchell SM; White R; Clark SJ; Molloy PL, 2005, 'Headloop suppression PCR and its application to selective amplification of methylated DNA sequences.', Nucleic acids research, 33
2005
Sidhu S; Martin E; Gicquel C; Melki J; Clark SJ; Campbell P; Magarey CJ; Schulte KM; Roher HD; Delbridge L; Robinson BG, 2005, 'Mutation and methylation analysis of TP53 in adrenal carcinogenesis', Eur J Surg Oncol, 31, pp. 549 - 554, http://dx.doi.org/10.1016/j.ejso.2005.01.013
2005
Stirzaker C; Song J; Davidson B; Clark SJ, 2004, 'Transcriptional Gene Silencing Promotes DNA Hypermethylation through a sequential Change in Chromatin Modifications in Cancer Cells', Cancer research, 64, pp. 3871 - 3877, http://dx.doi.org/10.1158/0008-5472.CAN-03-3690
2004
Noble JR; Zhong ZH; Neumann AA; Melki JR; Clark SJ; Reddel RR, 2004, 'Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts', Oncogene, 23, pp. 3116 - 3121, http://dx.doi.org/10.1038/sj.onc.1207440
2004
Clark SJ; Millar DS; Molloy P, 2003, 'Bisulfite methylation analysis of tumor suppressor genes in prostate cancer from fresh and archival tissue samples', Methods Mol Med, 81, pp. 219 - 240, http://dx.doi.org/10.1385/1-59259-372-0:219
2003
Schmitt JF; Millar DS; Pedersen JS; Clark SL; Venter DJ; Frydenberg M; Molloy PL; Risbridger GP, 2002, 'Hypermethylation of the inhibin α-subunit gene in prostate carcinoma', Molecular Endocrinology, 16, pp. 213 - 220, http://dx.doi.org/10.1210/me.16.2.213
2002
Clark SJ; Melki J, 2002, 'DNA methylation and gene silencing in cancer: which is the guilty party?', Oncogene, 21, pp. 5380 - 5387, http://dx.doi.org/10.1038/sj.onc.1205598
2002
Clark SJ; Warnecke PM, 2002, 'DNA methylation analysis in mammalian cells', Methods, 27, pp. 99 - 100, http://dx.doi.org/10.1016/S1046-2023(02)00059-2
2002
Millar DS; Warnecke PM; Melki JR; Clark SJ, 2002, 'Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells', Methods, 27, pp. 108 - 113, http://dx.doi.org/10.1016/S1046-2023(02)00061-0
2002
Schmitt JF; Millar DS; Pedersen JS; Clark SL; Venter DJ; Frydenberg M; Molloy PL; Risbridger GP, 2002, 'Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma', Mol Endocrinol, 16, pp. 213 - 220, http://dx.doi.org/10.1210/mend.16.2.0771
2002
Song JZ; Stirzaker C; Harrison J; Melki JR; Clark SJ, 2002, 'Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells', Oncogene, 21, pp. 1048 - 1061, http://dx.doi.org/10.1038/sj.onc.1205153
2002
Warnecke PM; Stirzaker C; Song J; Grunau C; Melki JR; Clark SJ, 2002, 'Identification and resolution of artifacts in bisulfite sequencing', Methods, 27, pp. 101 - 107, http://dx.doi.org/10.1016/S1046-2023(02)00060-9
2002
Rand K; Qu W; Ho T; Clark SJ; Molloy P, 2002, 'Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives', Methods, 27, pp. 114 - 120, http://dx.doi.org/10.1016/S1046-2023(02)00062-2
2002
Melki JR; Clark SJ, 2002, 'DNA methylation changes in leukaemia', Semin Cancer Biol, 12, pp. 347 - 357, http://dx.doi.org/10.1016/S1044-579X(02)00055-X
2002
Chetcuti A; Margan SH; Russell P; Mann S; Millar DS; Clark SJ; Rogers J; Handelsman DJ; Dong Q, 2001, 'Loss of annexin II heavy and light chains in prostate cancer and its precursors', Cancer Res, 61, pp. 6331 - 6334, http://www.ncbi.nlm.nih.gov/pubmed/11522620
2001
Grunau C; Clark SJ; Rosenthal A, 2001, 'Bisulfite genomic sequencing: systematic investigation of critical experimental parameters', Nucleic Acids Res, 29, pp. E65 - E65, http://www.ncbi.nlm.nih.gov/pubmed/11433041
2001
Welch J; Millar D; Goldman A; Heenan P; Stark M; Eldon M; Clark S; Martin NG; Hayward NK, 2001, 'Lack of genetic and epigenetic changes in CDKN2A in melanocytic nevi', J Invest Dermatol, 117, pp. 383 - 384, http://dx.doi.org/10.1046/j.0022-202x.2001.01391.x
2001
Grunau C; Renault E; Rosenthal A; Roizes G, 2001, 'MethDB - a public database for DNA methylation data', NUCLEIC ACIDS RESEARCH, 29, pp. 270 - 274, http://dx.doi.org/10.1093/nar/29.1.270
2001
Millar DS; Paul CL; Molloy PL; Clark SJ, 2000, 'A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5'-end of the GSTP1 CpG island', J Biol Chem, 275, pp. 24893 - 24899, http://dx.doi.org/10.1074/jbc.M906538199
2000
Melki JR; Vincent PC; Brown RD; Clark SJ, 2000, 'Hypermethylation of E-cadherin in leukemia', Blood, 95, pp. 3208 - 3213, http://www.ncbi.nlm.nih.gov/pubmed/10807790
2000
Jackson P; Millar D; Kingsley E; Yardley G; Ow K; Clark S; Russell PJ, 2000, 'Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines', Cancer Letters, 157, pp. 169 - 176, http://dx.doi.org/10.1016/S0304-3835(00)00483-3
2000
Jackson P; Mills DR; Kingsley EA; Yardley G; Ow KT; Clark SJ; Russell PJ, 2000, 'Methylation of a CpG island within the KAI1 promoter region is not responsible for reduced KAI1 expression in invasive bladder cancer or bladder cancer cell lines', Cancer Letters, 157, pp. 169 - 175
2000
Melki JR; Vincent PC; Clark SJ, 1999, 'Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia', Cancer Res, 59, pp. 3730 - 3740, http://www.ncbi.nlm.nih.gov/pubmed/10446989
1999
Millar DS; Ow KT; Paul CL; Russell PJ; Molloy PL; Clark SJ, 1999, 'Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer', Oncogene, 18, pp. 1313 - 1324, http://dx.doi.org/10.1038/sj.onc.1202415
1999
Molloy PL; Millar DS; Russell PJ; Clark SJ, 1999, 'Prostate Cancer DNA Methylation assay', Today's Life Science, 11, pp. 34 - 35
1999
Melki JR; Vincent PC; Clark SJ, 1999, 'Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia', Leukemia, 13, pp. 877 - 883, http://dx.doi.org/10.1038/sj.leu.2401401
1999
Veitch C; Harte J; Hays R; Pashen D; Clark S, 1999, 'Community participation in the recruitment and retention of rural doctors: methodological and logistical considerations.', The Australian journal of rural health, 7, pp. 206 - 211, http://dx.doi.org/10.1046/j.1440-1584.1999.00213.x
1999
Warnecke PM; Clark SJ, 1999, 'DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation', Mol Cell Biol, 19, pp. 164 - 172, http://www.ncbi.nlm.nih.gov/pubmed/9858541
1999
Warnecke PM; Biniszkiewicz D; Jaenisch R; Frommer M; Clark SJ, 1998, 'Sequence-specific methylation of the mouse H19 gene in embryonic cells deficient in the Dnmt-1 gene', Dev Genet, 22, pp. 111 - 121, http://dx.doi.org/10.1002/(SICI)1520-6408(1998)22:2<111::AID-DVG1>3.0.CO;2-9
1998
Huschtscha LI; Noble JR; Neumann AA; Moy EL; Barry P; Melki JR; Clark SJ; Reddel RR, 1998, 'Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells', Cancer Res, 58, pp. 3508 - 3512, http://www.ncbi.nlm.nih.gov/pubmed/9721850
1998
Warnecke PM; Mann JR; Frommer M; Clark SJ, 1998, 'Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene', Genomics, 51, pp. 182 - 190, http://dx.doi.org/10.1006/geno.1998.5371
1998
Melki JR; Warnecke P; Vincent PC; Clark SJ, 1998, 'Increased DNA methyltransferase expression in leukaemia', Leukemia, 12, pp. 311 - 316, http://dx.doi.org/10.1038/sj.leu.2400932
1998
Harrison J; Stirzaker C; Clark SJ, 1998, 'Cytosines adjacent to methylated CpG sites can be partially resistant to conversion in genomic bisulfite sequencing leading to methylation artifacts', Anal Biochem, 264, pp. 129 - 132, http://dx.doi.org/10.1006/abio.1998.2833
1998
Clark SJ; Harrison J; Molloy PL, 1997, 'Sp1 binding is inhibited by (m)Cp(m)CpG methylation', Gene, 195, pp. 67 - 71, http://dx.doi.org/10.1016/S0378-1119(97)00164-9
1997
Melki JR; Vincent PC; Clark SJ, 1997, 'DNA methylation in leukemia', Experimental Hematology, 25, pp. 855
1997
Stirzaker C; Millar DS; Paul CL; Warnecke PM; Harrison J; Vincent PC; Frommer M; Clark SJ, 1997, 'Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors', Cancer Research, 57, pp. 2229 - 2237
1997
Warnecke PM; Stirzaker C; Melki JR; Millar DS; Paul CL; Clark SJ, 1997, 'Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA', Nucleic Acids Res, 25, pp. 4422 - 4426, http://dx.doi.org/10.1093/nar/25.21.4422
1997
Paul CL; Clark SJ, 1996, 'Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN analysis', Biotechniques, 21, pp. 126 - 133, http://www.ncbi.nlm.nih.gov/pubmed/8816247
1996
Clark SJ; Harrison J; Frommer M, 1995, 'CpNpG methylation in mammalian cells', Nat Genet, 10, pp. 20 - 27, http://dx.doi.org/10.1038/ng0595-20
1995
Grigg G; Clark S, 1994, 'Sequencing 5-methylcytosine residues in genomic DNA', Bioessays, 16, pp. 431 - 436, http://dx.doi.org/10.1002/bies.950160612
1994
Clark SJ; Harrison J; Paul CL; Frommer M, 1994, 'High sensitivity mapping of methylated cytosines', Nucleic Acids Res, 22, pp. 2990 - 2997, http://dx.doi.org/10.1093/nar/22.15.2990
1994
Harrison J; Molloy PL; Clark SJ, 1994, 'Direct cloning of polymerase chain reaction products in an XcmI T-vector', Anal Biochem, 216, pp. 235 - 236, http://dx.doi.org/10.1006/abio.1994.1033
1994
Greenwood PE; Clark SJ; Cahill AD; Trevallyn-Jones J; Tzipori S, 1988, 'Development and protective efficacy of a recombinant-DNA derived fimbrial vaccine against enterotoxic colibacillosis in neonatal piglets', Vaccine, 6, pp. 389 - 392, http://www.ncbi.nlm.nih.gov/pubmed/3057758
1988
Sierra F; Leza A; Marashi F; Plumb M; Rickles R; Van Dyke T; Clark S; Wells J; Stein GS; Stein JL, 1982, 'Human histone genes are interspersed with members of the Alu family and with other transcribed sequences', Biochem Biophys Res Commun, 104, pp. 785 - 792, http://dx.doi.org/10.1016/0006-291X(82)90706-9
1982
Sierra F; Lichtler A; Marashi F; Rickles R; Van Dyke T; Clark S; Wells J; Stein G; Stein J, 1982, 'Organization of human histone genes', Proc Natl Acad Sci U S A, 79, pp. 1795 - 1799, http://dx.doi.org/10.1073/pnas.79.6.1795
1982
Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proceedings of the National Academy of Sciences of the United States of America, 79, pp. 749 - 753, http://dx.doi.org/10.1073/pnas.79.3.749
1982
Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proc Natl Acad Sci U S A, 79, pp. 749 - 753, http://dx.doi.org/10.1073/pnas.79.3.749
1982
Lichtler AC; Sierra F; Clark S; Wells JR; Stein JL; Stein GS, 1982, 'Multiple H4 histone mRNAs of HeLa cells are encoded in different genes', Nature, 298, pp. 195 - 198, http://dx.doi.org/10.1038/298195a0
1982
Clark SJ; Krieg PA; Wells JR, 1981, 'Isolation of a clone containing human histone genes', Nucleic Acids Res, 9, pp. 1583 - 1590, http://dx.doi.org/10.1093/nar/9.7.1583
1981
Preprints
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Schmitz U; Shah JS; Dhungel BP; Monteuuis G; Luu P-L; Petrova V; Metierre C; Nair SS; Bailey CG; Saunders VA; Turhan AG; White DL; Branford S; Clark S; Hughes TP; Wong JJ-L; Rasko JEJ, 2020, Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukemia patients, , http://dx.doi.org/10.1101/2020.07.31.20165597
2020
Luu P-L; Ong P-T; Loc TTH; Lam D; Pidsley R; Stirzaker C; Clark SJ, 2020, MethPanel: a parallel pipeline and interactive analysis tool for multiplex bisulphite PCR sequencing to assess DNA methylation biomarker panels for disease detection, , http://dx.doi.org/10.1101/2020.02.09.941013
2020
Schumann U; Zhang H-N; Sibbritt T; Pan A; Horvath A; Gross S; Clark SJ; Yang L; Preiss T, 2020, Multiple links between 5-methylcytosine content of mRNA and translation, , http://dx.doi.org/10.1101/2020.02.04.933499
2020
Du Q; Bert SA; Armstrong NJ; Caldon CE; Song JZ; Nair SS; Gould CM; Luu PL; Khoury A; Qu W; Zotenko E; Stirzaker C; Clark SJ, 2018, Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements, , http://dx.doi.org/10.1101/251280
2018
Milevskiy MJG; Gujral U; Lama Marques CD; Stone A; Northwood K; Burke LJ; Gee JMW; Nephew K; Clark S; Brown MA, 2018, MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ Breast Cancer, , http://dx.doi.org/10.1101/329227
2018
O'Donoghue SI; Baldi BF; Clark SJ; Darling AE; Hogan JM; Kaur S; Maier-Hein L; McCarthy DJ; Moore WJ; Stenau E; Swedlow JR; Vuong J; Procter JB, 2018, Visualization of Biomedical Data, , http://dx.doi.org/10.7287/peerj.preprints.26896
2018
O'Donoghue SI; Baldi BF; Clark SJ; Darling AE; Hogan JM; Kaur S; Maier-Hein L; McCarthy DJ; Moore WJ; Stenau E; Swedlow JR; Vuong J; Procter JB, 2018, Visualization of Biomedical Data, , http://dx.doi.org/10.7287/peerj.preprints.26896v1
2018
Riebler A; Menigatti M; Song JZ; Statham AL; Stirzaker C; Mahmud N; Mein CA; Clark SJ; Robinson MD, 2013, BayMeth: Improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach, , http://dx.doi.org/10.48550/arxiv.1312.3115
2013
Conference Abstracts
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Tiedemann R; Du Q; Dickson B; Kong X; Chomiak A; Zhou W; Johnson B; Baylin S; Jones P; Clark S; Rothbart S, 2020, 'High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.05966
2020
Stirzaker C; Chia KM; Portman N; Milioli HH; Clifton S; Achinger-Kawecka J; Nair S; Lim E; Clark S, 2019, 'DNA demethylation agents as a therapeutic approach in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P049
2019
Horvath LG; Mahon KL; Qu W; Lin HM; Spielman C; Cain D; Jacobs C; Stockler MR; de Bono JS; Higano CS; Chi KN; Clark SJ, 2018, 'Post Hoc Analysis of a Phase III Study to Test the Association Between Circulating Methylated Glutathione S Transferase (mGSTP1) DNA Levels and Response to Docetaxel (DTX) in Metastatic Castration-Resistant Prostate Cancer (mCRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 14, pp. 51 - 52, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000439493100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Mathe A; Wong-Brown M; Morten BC; Braye SG; Locke WJ; Stirzaker C; Clark SJ; Scott R; Avery-Kiejda KA, 2018, 'Defining the Key Mediators of Breast Cancer Progression and Treatment Resistance in the triple Negative Subtype', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 14, pp. 9 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446654600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Mathe A; Wong-Brown M; Locke W; Stirzaker C; Braye S; Forbes J; Clark S; Avery-Kiejda K; Scott R, 2016, 'DNA METHYLATION PROFILE OF TRIPLE NEGATIVE BREAST CANCER-SPECIFIC GENES COMPARING LYMPH NODE POSITIVE PATIENTS TO LYMPH NODE NEGATIVE PATIENTS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 27 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387772400056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Vuocolo T; Statham A; Bauer DC; McWilliam S; Nair SS; Morrison JL; Zhang S; Buckley M; McMillen IC; Clark SJ; Tellam RL, 2016, 'A hierarchy of epigenetic changes in the developmental transition from brown to white perirenal adipose tissue.', in JOURNAL OF ANIMAL SCIENCE, OXFORD UNIV PRESS INC, Vol. 94, pp. 9 - 10, http://dx.doi.org/10.2527/jas2016.94supplement49a
2016
Gallego-Ortega D; Ledger A; Roden D; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Lee B; Kaplan W; Salomon R; Piggin C; Rabinovich B; Millar E; Chtanova T; Swarbrick A; Clark S; Ormandy C, 2015, 'The ETS transcription factor ELF5 drives metastasis via angiogenesis and recruitment of Gr-1+ CD11b+ myeloid derived suppressor cells in luminal breast cancer', in Clinical and Experimental Metastasis, Springer Verlag (Germany), Vol. 32, pp. 203 - 203, presented at MRS 15th International biennial congress of the metastasis research society, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351601900067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2015
Lawrence M; Pidsley R; Ellem S; Furic L; Nair S; French H; Statham A; Larsson O; Frydenberg M; Pedersen J; Buchanan G; Taylor R; Clark S; Risbridger G, 2015, 'Surveying the epigenome landscape of the prostate cancer microenvironment: identification of estrogen receptor alpha as a key differentially methylated gene', in CLINICAL ENDOCRINOLOGY, WILEY, AUSTRALIA, Adelaide, Vol. 84, pp. 20 - 20, presented at Annual Scientific Meeting of the Endocrine-Society-of-Australia, AUSTRALIA, Adelaide, 23 August 2015 - 26 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372310400056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Conference Papers
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Lawrence MG; Pidsley R; Zotenko E; Niranjan B; Statham A; Song J; Armstrong N; Pedersen J; Frydenberg M; Taylor R; Stirzaker C; Risbridger G; Clark S, 2017, 'Abstract 1997: Charting the DNA methylation landscape of prostate cancer associated fibroblasts', in Cancer Research, American Association for Cancer Research (AACR), pp. 1997 - 1997, presented at Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC, http://dx.doi.org/10.1158/1538-7445.am2017-1997
2017
Milevskiy MJ; Al-Ejeh F; Saunus JM; Northwood KS; McCart-Reed AE; Dray E; Nephew K; Bailey PJ; Betts JA; Stone A; Gee JMW; Shewan AM; French JD; Edwards SL; Clark SJ; Lakhani SR; Brown MA, 2016, 'Abstract 1980: Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability', in Cancer Research, American Association for Cancer Research (AACR), pp. 1980 - 1980, presented at Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA, http://dx.doi.org/10.1158/1538-7445.am2016-1980
2016
Clark SJ, 2014, 'EPIGENETIC REMODELING AND REPLICATION TIMING IN CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 28 - 28, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Clark S, 2014, 'WHOLE GENOME METHYLATION SEQUENCING IDENTIFIES POTENTIAL EPIGENETIC-BASED CANCER BIOMARKERS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 18 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Mahon K; Qu W; Devaney J; Paul C; Castillo L; Chatfield M; Boyer M; Stockler M; Marx G; Gurney H; Mallesara G; Molloy P; Horvath L; Clark S, 2014, 'METHYLATED GLUTATHIONE S-TRANSFERASE 1 (MGSTP1) ASA POTENTIAL PLASMA EPIGENETIC MARKER OF PROGNOSIS AND RESPONSE TO CHEMOTHERAPY IN CASTRATE-RESISTANT PROSTATE CANCER (CRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 27 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler M; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark S; Swarbrick A; Daly R; Horvath L, 2014, 'CIRCULATING MICRORNAS ASSOCIATED WITH DOCETAXEL-RESISTANT CASTRATION-RESISTANT PROSTATE CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 26 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Stirzaker C; Song JZ; Statham AL; Robinson M; Lacaze P; Coolen M; Moreno CS; Warren K; Clark SJ, 2009, 'CONSOLIDATION OF THE CANCER EPIGENOME TO REGIONS OF UNIFORM CHROMATIN', in CELLULAR ONCOLOGY, SPRINGER, SCOTLAND, Edinburgh, pp. 101 - 101, presented at 3rd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SCOTLAND, Edinburgh, 01 April 2009 - 05 April 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265635300028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2009
Stirzaker C; Song JZ; Statham AL; Robinson M; Lacaze P; Coolen M; Moreno CS; Warren K; Clark SJ, 2009, 'CONSOLIDATION OF THE CANCER EPIGENOME TO REGIONS OF UNIFORM CHROMATIN', in CELLULAR ONCOLOGY, IOS PRESS, SCOTLAND, Edinburgh, pp. 136 - 136, presented at 3rd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SCOTLAND, Edinburgh, 01 April 2009 - 05 April 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265635300098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2009
Coolen M; Song J; Statham AL; Lacaze P; Moreno CS; Kaplan W; Stirzaker C; Clark SJ, 2008, 'Long range epigenetic silencing (LRES): A common phenomenon in prostate cancer', in CELLULAR ONCOLOGY, IOS PRESS, SPAIN, Madrid, pp. 225 - 225, presented at 2nd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SPAIN, Madrid, 04 May 2008 - 07 May 2008, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255341800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2008
Frigola J; Song JZ; Stirzaker C; Peinado MA; Clark SJ, 2006, 'Epigenetic Silent Neighborhoods in Cancer Cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606204232&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2006
Melki JR; Vincent PC; Clark SJ, 1997, 'DNA methylation in leukemia.', in EXPERIMENTAL HEMATOLOGY, CARDEN JENNINGS PUBL CO LTD, pp. 444 - 444, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XR33000430&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
1997
Books
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Coolen MW; Clark SJ, 2011, Epigenetics: A Reference Manual, Original, Caister Academic Press, UK, http://www.horizonpress.com/epigenetics
2011

AWARDS
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2020 - Elected a Fellow of the Australian Academy of Health and Medical Sciences

2019 - NSW Premiers Prize for Excellence in Medical Biological Sciences

2019 - Senior Principal Research Fellowship (NHMRC)

2017 - The Clive and Vera Ramaciotti Foundation: 2017 Medal of Excellence for Biological
Science ($50K)

2015 - Elected a Fellow of the Australian Academy of Science

2015 - CINSW Award: The Rob Sutherland Make a Difference Award ($20K)

2015 - Nadine Watson Lecture Award for a Leading Female scientist

2014 - Senior Principal Research Fellowship (NHMRC)

2012 - Rotary Award for Vocational Excellence

2011 - Victor Chang Medal (Barbara Ell Seminar Series Lecturer)

2010 - Service to Science and Industry, North Shore Times, 50 year medal

2009 - Australia’s “Top Ten” (NHMRC) Scientist Award

2009 - Promoted Senior Principal Research Fellow (Garvan Institute)

2008 - Principal Research Fellowship (NHMRC)

2008 - Adjunct Professor, Faculty Medicine, University of NSW

2008 - Director’s Inaugural Women in Science Lecture Award (WEHI)

2006 - World Technology Award, finalist for Biotechnology: the most innovative people in the science and technology world in 2006

2006 - Elected a Fellow of the World Technology Network for Biotechnology for contribution to Epigenetics technology

2004 - Principal Research Fellowship (NHMRC)

2004 - The Ruby Payne-Scott Award Lecture for women in Australian science

2004 - German Science Prize “Biochemisch Analytik Preis” (50,000 Euros) for outstanding contribution for Methylation analysis.

Since 1970, this award has recognized the work of 27 world-renowned scientists,  four of whom have subsequently gone on to win a Nobel Prize

2003 - Julian Wells Medal for “outstanding contribution to gene action and genome structure”, Lorne Genome conference

2002 - RPAH Research Medal for $50,000 for major contribution to research

1998 - Cancer Council NSW Travelling Award

1997 - DNA Methylation Imprinting and the Epigenetics of Cancer, AACR, Research Presentation Award, Puerto Rico

1978 - Commonwealth Post Graduate Research Award

1976 - CRAC Undergraduate Exchange Travelling Award to study at Cambridge

1975 - Commonwealth University Scholarship

 

GRANTS
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CURRENT

2023-2025: NHMRC Ideas Grant # 2020334
Title: Functional impact of CTCF binding site mutations in 3D cancer genome regulation.
CIA Clark S, Khoury A

2022-2024: NHMRC Ideas Grant #App 2012072
Title: 3D Nuclear Re-organisation Potentiates Genomic Structural Variations in Prostate Cancer
CIA Clark SJ, Stirzaker, C

2019-2023: NHMRC Senior Principal Research Fellowship # APP1156408
Title: Unravelling The Cancer Epigenome: Mechanisms to Translation
CIA Clark SJ

 

Tags
lensCancer
Organisational units
lensChief Investigators